What is the major side effect associated with the use of phenothiazines?

Phenothiazines, which are commonly used as antipsychotic medications, are primarily associated with extrapyramidal symptoms (EPS), which can include a range of movement disorders. Among the various side effects, photosensitivity is prominently noted. This side effect occurs because phenothiazines can make the skin more sensitive to sunlight, leading to an increased risk of sunburn or rashes when exposed to UV light.

Photosensitivity results from the drug's interaction with light and can lead to discomfort and adverse skin reactions, making it crucial for patients on phenothiazines to take precautions against sun exposure. Understanding this risk is essential for effective patient education, as well as for the health and safety of individuals taking these medications.

Nausea, respiratory depression, and headaches are other potential side effects seen with various medications but are not considered the major side effect associated specifically with phenothiazines. Recognizing the distinct profile of side effects for different drug classes is key for safe medication management and patient care.