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Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, inflammation, and fever. One notable side effect associated with naproxen is gastric irritation. This occurs because NSAIDs can inhibit the production of prostaglandins, which are substances that help protect the stomach lining. When the protective lining is compromised, the stomach becomes more susceptible to irritation and ulceration, leading to symptoms such as nausea, heartburn, stomach pain, or even gastrointestinal bleeding in more severe cases.

The other side effects listed do not have a direct and common association with naproxen. For instance, while constipation can occur with various medications, it is not considered a prevalent side effect of naproxen. Weight gain is not typically linked to its use, and blurry vision is also not a recognized common side effect of this medication. Therefore, gastric irritation stands out as a direct and well-documented side effect related to naproxen usage.

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